Ep 141: “iPSC-Derived Myogenic Progenitors” Featuring Dr. Rita Perlingeiro

Guest: Dr. Rita Perlingeiro is the Lillehei Professor in Stem Cell and Regenerative Cardiovascular Medicine at the Lillehei Heart Institute. Her lab is interested in understanding the molecular mechanisms controlling lineage-specific differentiation of pluripotent stem cells, and applying this information to generate tissue-specific stem/progenitor cells endowed with in vivo regenerative potential. Much of her work is focused on muscular dystrophies. Featured Products and Resources: Muscle Cell News MyoCult™ Resources and Links New CAR T-Cell Therapy Less Toxic - A Phase I clinical trial has shown that a redesigned CAR T-cell molecule was less toxic and produced fewer side effects in patients, making the treatment safer. Using MSCs to Engineer an HSC Niche - Researchers have identified genes in mesenchymal stem cells that enhanced the production of niche factors that could maintain hematopoietic stem cells in culture. Generating Ovarian Cancer Organoids - Investigators developed a protocol for generating and expanding ovarian cancer organoids, and demonstrated their potential applications. Stress-Resistant Muscle Stem Cells - Scientists have identified a population of muscle stem cells that resist radiation and are able to expand under severe stress. Muscle Stem Cells Protected from Environmental Stress - The expression of a transcription factor has been shown to protect muscle stem cells against environmental stress caused by a toxic pollutant.   Photo Reference: Courtesy of Dr. Rita Perlingeiro #footable_5807 { font-family: inherit; font-size: 14px; } #footable_parent_5807 thead { display: none; } #footable_parent_5807 a.nt_edit_link { display: none; } #footable_parent_5807 td { border-color: #fff; } #footable_parent_5807 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_5808 { font-family: inherit; font-size: 14px; } thead { display: none; } #footable_parent_5808 a.nt_edit_link { display: none; } #footable_parent_5808 td { border-color: #fff; } #footable_parent_5808 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_5807 { font-family: inherit; font-size: 14px; } #footable_parent_5807 thead { display: none; } #footable_parent_5807 a.nt_edit_link { display: none; } #footable_parent_5807 td { border-color: #fff; } #footable_parent_5807 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; }