EA - Biosafety in BSL-3, BSL-3+ and BSL-4 Laboratories: Mapping and Recommendations for Latin America by JorgeTorresC

Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Biosafety in BSL-3, BSL-3+ and BSL-4 Laboratories: Mapping and Recommendations for Latin America, published by JorgeTorresC on August 23, 2023 on The Effective Altruism Forum.Executive summaryThis article addresses biosafety and biosecurity in high-containment level laboratories (BSL-3 and BSL-4) in Latin America, with a focus on classification, current status, and regulatory frameworks. In the region, the lack of uniformity in data collection makes it difficult to accurately understand the infrastructure of high-containment laboratories. Regulatory frameworks vary across the region and present challenges in terms of standardization. Although countries like Colombia have made progress in this area, there is a need to establish updated and centralized regulatory frameworks in each country.To improve biosafety and biosecurity, we make a series of recommendations such as the implementation of biological risk management systems in laboratories, the promotion of non-punitive incident reports, the standardization of supervision processes, collaboration between institutions, and the exchange of best practices.IntroductionBiosafety and biosecurity in high-containment level laboratories (BSL-3 and BSL-4) are of vital importance for the protection of public health. These laboratories work with dangerous biological agents, so it is essential to ensure that practices, equipment, and security measures are adequate and rigorous. In this context, this article focuses on analyzing the current situation of BSL-3, BSL-3+, and BSL-4 laboratories in Latin America. We explore the increase in the construction of these laboratories at a global level, the regulatory frameworks by which they are governed, and the challenges that some Latin American countries face in their implementation. In addition, we propose several recommendations to improve biosafety and biosecurity in these laboratories.To consult the complete map follow the link:Classification of laboratories by biosafety levelsIn 1974, the United States Centers for Disease Control and Prevention (CDC) published a document titled "Classification of etiologic agents on the basis of hazard", proposing the classification of pathogens into four risk groups. Subsequently, both the National Institutes of Health (NIH) of the United States and the World Health Organization (WHO) updated this system, thus establishing the bases for the classification of laboratories according to the risk group of the pathogens they handle (Villegas et al. al., 2007). Out of the classification of risk groups, four levels of biosafety in laboratories have been established. These levels are determined taking into account several factors, such as the infectious capacity of the pathogen, the existence of treatments or vaccines for it, the severity of the disease it causes, its transmissibility, whether it is of exotic origin or not, and the nature of the work carried out in the laboratory (Lara-Villegas et al., 2008).Level 1 (BSL-1) laboratories use elemental equipment and practices for teaching purposes. They work with well-defined and characterized strains of microorganisms that do not cause disease in healthy people. The use of special protective equipment is not required.Level 2 (BSL-2) laboratories adopt appropriate practices, equipment, and measures to realize clinical analysis, diagnoses, and pathology. These laboratories handle microorganisms of moderate risk that are present in the community and are associated with human diseases of variable severity.Level 3 (BSL-3) laboratories implement appropriate practices, equipment, and measures to realize clinical analysis, diagnoses, and research. These laboratories handle known or unknown agents that have the potential to be transmitted by aerosol or splash and that can cause life-threatening infections...