In this episode, Marc and Mo discuss the topic of amputation surgery in diabetic patients, with a specific focus on the risk factors for failure following transmetatarsal amputation, the challenges to performing RCTs in this area of orthopaedics, and the need for collaborative multidisciplinary/multi-institutional consortia focused on this important topic.    Links:  Ron I, Kyin C, Peskin B, Ghrayeb N, Norman D, Ben-Kiki T, Shapira J. Risk Factors for a Failed Transmetatarsal Amputation in Patients with Diabetes. J Bone Joint Surg Am. 2023 May 3;105(9):651-658. doi: 10.2106/JBJS.22.00718. Epub 2023 Mar 21. PMID: 36943915. https://bit.ly/3o72Et0    OrthoEvidence. Fenofibrate produces a reduction in amputation events in type II diabetics. ACE Report. 2013;2(4):82. Available from: https://myorthoevidence.com/AceReport/Report/333                        Subspecialties:  Ethics