Your parent's diet and exercise affects your health with Dr Laurie Goodyear
Dr Glenn McConell chats with Professor Laurie Goodyear from the Joslin Diabetes Centre at Harvard Medical School. Laurie is a very big name in the field of exercise metabolism with a remarkable track record. She has examined glucose and fat metabolism during exercise and more recently has been focusing on developmental origins of health and disease and the benefits of exercise. Exercise of the mother, the father and even the grandmother has beneficial effects on offspring, especially if the parents were on a high fat diet. The role of epigenetics is discussed. 0:00. Introduction 3:20. How Laurie ended up in exercise research. Started off very applied and then mechanistic. 8:02. Developmental origins of health and disease. Dutch famine etc. 12:22. Rodents allow observations over a lifetime. 13:00. Genetics and epigenetics 17:30. What you do during your life affects what’s passed on 18:30. Maternal exercise and offspring health. High fat diets with and without exercise 25:50. Effects on the placenta /liver SOD3 activates AMPK. Need normal Vitamin D and exercise 28:20. Human studies appear to fit with the rodent findings 33:00. Paternal exercise and offspring health High fat diets with and without exercise 37:40. Grand-maternal exercise 40:29. Voluntary wheel running 42:08. Recommendations before conceive 44:00. Translation of mice running wheel results to humans. Normally active is the control. Sedentary behaviour is the treatment. 49:36. Real life: Things not working in the lab 52:34. How much the high fat diet vs obesity? 54:38. Exercise early in life can overcome issues. Pancreas. 58:10. Organ cross talk. Fat cells and exercise. Adipokines. Lactate signaling the adipose tissue. 1:01:03. Take away messages. Inside Exercise brings to you the who's who of exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all. The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University. He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9). Connect with Inside Exercise and Glenn McConell at: Twitter: @Inside_exercise and @GlennMcConell1 Instagram: insideexercise Facebook: Glenn McConell LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460 ResearchGate: Glenn McConell Email: [email protected] Subscribe to Inside exercise: Spotify: https://open.spotify.com/show/3pSYnNSXDkNLH8rImzotgP?si=Whw_ThaERF6iIKwxutDoNA Apple Podcasts: https://podcastsconnect.apple.com/my-podcasts/show/inside-exercise/03a07373-888a-472b-bf7e-a0ff155209b2 Google Podcasts: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy84ZTdiY2ZkMC9wb2RjYXN0L3Jzcw Anchor: https://anchor.fm/insideexercise Podcast Addict: https://podcastaddict.com/podcast/4025218 YouTube: youtube.com/@insideexercise